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The inability to comprehend significant events is commonly associated with Post-Traumatic Stress Disorder (PTSD). Individuals who have experienced trauma may struggle with processing their experiences, as the emotional and psychological impact can disrupt their cognitive functions. This can manifest in various ways, such as difficulty concentrating, memory problems, or feeling detached from the events that occurred.

In PTSD, the trauma can create a barrier to understanding or integrating the traumatic event into one's life narrative. This disconnection is often a protective mechanism that helps the individual cope with overwhelming distress. People with PTSD may relive the trauma through flashbacks or nightmares but simultaneously find it challenging to articulate or make sense of what happened.

While anxiety, depression, and substance abuse can also affect cognitive processing and comprehension, they typically do not specifically encapsulate that particular disconnect with significant events as prominently as PTSD does.